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M9640664.TXT
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1996-03-04
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Document 0664
DOCN M9640664
TI Thyroid abnormalities in children infected with human immunodeficiency
virus.
DT 9604
AU Hirschfeld S; Laue L; Cutler GB Jr; Pizzo PA; Pediatric Branch, National
Cancer Institute, National Institutes; of Health, Bethesda, Maryland
20892, USA.
SO J Pediatr. 1996 Jan;128(1):70-4. Unique Identifier : AIDSLINE
MED/96144596
AB OBJECTIVE: To study thyroid function in children infected with human
immunodeficiency virus (HIV) and determine whether there are correlates
of thyroid dysfunction with disease progression. STUDY DESIGN: Total and
free thyroxine, triiodothyronine, reverse triiodothyronine, thyrotropin,
and thyroxine binding globulin (TBG) were measured in 167 children with
HIV infection (age, 1 to 19 years; mean, 9.15 years). SETTING: Pediatric
Branch, National Cancer Institute. RESULTS: Free thyroxine was at or
below the lower limit of normal (normal, 1.0 to 1.9 ng/dl) in 18% of the
children; thyrotropin and TBG levels were above the normal range in 31%
and 30%, respectively. There was an inverse correlation between CD4+
cell count and thyrotropin, and between CD4+ cell count and TBG. No
correlation was found between thyroid function and other disease
symptoms or medications. CONCLUSION: These findings indicate that
thyroid abnormalities occur more frequently in children with HIV
infection than was previously reported, have a different profile from
the thyroid abnormalities associated with other chronic disease
conditions, and correlate with disease progression.
DE Adolescence Analysis of Variance Child Child, Preschool CD4
Lymphocyte Count Disease Progression Female Human HIV
Infections/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY Male Prevalence
Regression Analysis Thyroid Gland/*PHYSIOPATHOLOGY Thyroid
Hormones/*BLOOD JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).